Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.
Identifieur interne : 003031 ( Main/Exploration ); précédent : 003030; suivant : 003032Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.
Auteurs : Yugeesh R. Lankadeva [Australie] ; Lindsea C. Booth ; Junko Kosaka ; Roger G. Evans ; Luc Quintin ; Rinaldo Bellomo ; Clive N. MaySource :
- Critical care medicine [ 1530-0293 ] ; 2015.
Descripteurs français
- KwdFr :
- Agonistes des récepteurs alpha-2 adrénergiques (pharmacologie), Angiotensine-II (pharmacologie), Animaux, Clonidine (pharmacologie), Femelle, Hypotension artérielle (physiopathologie), Hypotension artérielle (étiologie), Ovis, Phényléphrine (pharmacologie), Pression sanguine (), Rein (innervation), Sepsie (), Sepsie (physiopathologie), Système nerveux sympathique (), Système nerveux sympathique (physiopathologie), Vasoconstricteurs (pharmacologie).
- MESH :
- pharmacologie : Agonistes des récepteurs alpha-2 adrénergiques, Angiotensine-II, Clonidine, Phényléphrine, Rein, Vasoconstricteurs.
- physiopathologie : Hypotension artérielle, Sepsie, Système nerveux sympathique.
- étiologie : Hypotension artérielle.
- Animaux, Femelle, Ovis, Pression sanguine, Sepsie, Système nerveux sympathique.
English descriptors
- KwdEn :
- Adrenergic alpha-2 Receptor Agonists (pharmacology), Angiotensin II (pharmacology), Animals, Blood Pressure (drug effects), Clonidine (pharmacology), Female, Hypotension (etiology), Hypotension (physiopathology), Kidney (innervation), Phenylephrine (pharmacology), Sepsis (complications), Sepsis (physiopathology), Sheep, Sympathetic Nervous System (drug effects), Sympathetic Nervous System (physiopathology), Vasoconstrictor Agents (pharmacology).
- MESH :
- chemical , pharmacology : Adrenergic alpha-2 Receptor Agonists, Angiotensin II, Clonidine, Phenylephrine, Vasoconstrictor Agents.
- complications : Sepsis.
- drug effects : Blood Pressure, Sympathetic Nervous System.
- etiology : Hypotension.
- innervation : Kidney.
- physiopathology : Hypotension, Sepsis, Sympathetic Nervous System.
- Animals, Female, Sheep.
Abstract
In sepsis, prolonged, sympathetic overstimulation may lead to vasopressor-refractory hypotension. We therefore examined the effects of the α2-adrenergic agonist clonidine on mean arterial pressure, renal sympathetic nerve activity, and pressor responsiveness to phenylephrine and angiotensin II during hypotensive sepsis in conscious sheep.
DOI: 10.1097/CCM.0000000000000963
PubMed: 25860204
Affiliations:
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Le document en format XML
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We therefore examined the effects of the α2-adrenergic agonist clonidine on mean arterial pressure, renal sympathetic nerve activity, and pressor responsiveness to phenylephrine and angiotensin II during hypotensive sepsis in conscious sheep.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name><name sortKey="Booth, Lindsea C" sort="Booth, Lindsea C" uniqKey="Booth L" first="Lindsea C" last="Booth">Lindsea C. Booth</name><name sortKey="Evans, Roger G" sort="Evans, Roger G" uniqKey="Evans R" first="Roger G" last="Evans">Roger G. Evans</name><name sortKey="Kosaka, Junko" sort="Kosaka, Junko" uniqKey="Kosaka J" first="Junko" last="Kosaka">Junko Kosaka</name><name sortKey="May, Clive N" sort="May, Clive N" uniqKey="May C" first="Clive N" last="May">Clive N. May</name><name sortKey="Quintin, Luc" sort="Quintin, Luc" uniqKey="Quintin L" first="Luc" last="Quintin">Luc Quintin</name></noCountry><country name="Australie"><region name="Victoria (État)"><name sortKey="Lankadeva, Yugeesh R" sort="Lankadeva, Yugeesh R" uniqKey="Lankadeva Y" first="Yugeesh R" last="Lankadeva">Yugeesh R. Lankadeva</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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